Bioactive Small Molecules
Cayman Chemical diABZI STING Agonist-1 hydro
An activator of the STING pathway; induces secretion of IFN-β in human PBMCs (EC50 = 130 nM); increases serum levels of Ifn-β, Il-6, Tnf, and Cxcl1 in wild-type, but not Sting-/-, mice at 2.5 mg/kg; inhibits the cytopathic effect of HCoV-229E in infected MRC-5 cells (EC50 = 3 nM); decreases the levels of SARS-CoV-2 RNA in primary human bronchial airway epithelial cells in an air-liquid interface assay; decreases tumor volume and increases survival in a CT26 murine colorectal cancer model at 3 mg/kg; this compound is expected to exist in one or both tautomeric forms
Cayman Chemical SR-17018, Purity: ≥98%, CAS: 2134602-45-0, 25 mg
An analytical reference standard categorized as an opioid; increases latency to withdraw in the hot plate and warm water tail-flick assay without inducing respiratory depression in mice; induces place preference in a conditioned place preference test; induces antinociceptive tolerance after repeated administration in mice; intended for research and forensic applications
Cayman Chemical Diprotin A, Purity: ≥98%, CAS: 90614-48-5, 25 mg
A tripeptide inhibitor of DPP-4 (IC50 = 1.1 μg/ml); inhibits degradation of GLP-1 in culture with insulin-secreting BRIN-BD11 rat pancreatic β-cells at 25 μM; pre-incubation at 5 mg/ml enhances chemotaxis of murine embryonic stem cells towards SDF-1/CXCL12 in vitro; pre-incubation of CD34+ human umbilical cord blood cells with 5 mM prior to injection increases engraftment in NOD/SCID recipient mice
Cayman Chemical AZ 7550 (hydrochloride), Purity: ≥98%, 5 mg
An active metabolite of AZ 9291; inhibits IGF-1R in a cell-free assay (IC50 = 1.6 µM); inhibits EGFR autophosphorylation in H1975 cells expressing EGFRT790M/L858R, PC-9 cells expressing EGFRExon19del, and LoVo cells expressing wild-type EGFR (IC50s = 0.045, 0.026, and 0.786 µM, respectively)
Medchemexpress LLC PACAP (6-38), human, ovine, rat | 143748-18-9 | 99.1% | 4024.74 | 5 MG
PACAP (6-38), human, ovine, rat TFA is a potent PACAP receptor antagonist with IC50s of 30 nM for the PACAP type I receptor, 600 nM for the PACAP type II receptor VIP1, and 40 nM for the PACAP type II receptor VIP2. It inhibits the increase of dopamine content and cell proliferation induced by Dexamethasone in PC12 cells.
- Potent PACAP receptor antagonist
- Inhibits PACAP type 1 (PAC1) receptor
- Increases intercontraction interval and void volume in NGF-OE mice
- Decreases baseline bladder pressure in NGF-OE mice
- Reduces pelvic sensitivity in NGF-OE mice
- For research use only
Cell Signaling Technology Etoposide, Topoisomerase II Inhibitor, >98% Purity, 5.9 mg
Etoposide (VP-16) is an anti-tumor agent that functions as a topoisomerase II inhibitor. It stabilizes the covalent topoisomerase II-cleaved DNA intermediate complex, leading to genomic instability and cell death, and is commonly used as an apoptosis inducer. This chemical modulator is supplied as a lyophilized powder.
- IC50: 59.2 μM
- Purity: >98%
- Mechanism of action: Stabilizes covalent topoisomerase II-cleaved DNA intermediate complex, delaying cell cycle progression through late S and early G2 phases
- Reconstitution: For a 25 mM stock solution, reconstitute the 5.9 mg in 400 μL DMSO
- Solubility: 25 mg/mL in DMSO
- Typical usage: 5–50 μM for 4–24 hr treatments
- Storage: Store lyophilized or in solution at -20°C, desiccated
Medchemexpress LLC Laduviglusib (CHIR-99021) | 252917-06-9 | MFCD11846251 | 99.1% | 465.3 g·mol⁻¹ | C22H18Cl2N8 | 5 MG
Laduviglusib (CHIR-99021) analytical standard is a potent, selective GSK-3α/β inhibitor supplied as a solid reference material for research and analytical applications. It is intended for use as a reference standard in assay development, compound characterization, and analytical calibration, and is provided in small pack sizes suitable for laboratory workflows.
- Analytical standard for assay development and compound characterization
- High purity, 99.1% (assay) for reliable analytical performance
- Off-white to light yellow solid suitable for weighing and formulation
- Small pack size available (5 MG) for reference use
- Molecular formula C22H18Cl2N8; molecular weight 465.3 g·mol⁻¹
Medchemexpress LLC Exendin-4 (exenatide) | 141758-74-9 | 100.0% | C184H282N50O60S | 10MG
Exendin-4 (exenatide) is a 39-amino-acid peptide agonist of the glucagon-like peptide-1 (GLP-1) receptor used in research to investigate GLP-1 signaling, insulin secretion, and metabolic effects. It is provided as a high-purity powder with documented sequence, potency, solubility guidance, and storage recommendations for laboratory use.
- High receptor potency (IC50 ~3.22 nM) for GLP-1 studies.
- Full 39-amino-acid sequence provided for experimental planning.
- Supplied as a powder suitable for long-term storage at -80°C.
- Soluble in DMSO and water; sonication recommended for dissolution.
- High purity suitable for biochemical and cell-based assays.
Medchemexpress LLC Janelia Fluor 646, SE (NHS ester) | 1811539-59-9 | 99.7% | 593.7 g/mol | C33H31N3O6Si | 5 MG
Janelia Fluor 646, SE is a far-red succinimidyl ester dye for covalent labeling of primary amines, designed for fluorescence microscopy and live-cell applications. The reagent provides bright, photostable far-red emission and is formulated for reliable conjugation and imaging performance.
- Bright far-red fluorescence with excitation ~646 nm and emission ~664 nm.
- High photostability for prolonged imaging sessions.
- Reactive succinimidyl ester for efficient amine conjugation.
- Suitable for confocal, super-resolution, and live-cell imaging.
- High chemical purity for consistent labeling results.
Medchemexpress LLC Lalistat 2 | 1234569-09-5 | MFCD31544494 | 99.9% | 296.39 | C13H20N4O2S | 5 MG
Lalistat 2 is a small-molecule inhibitor of lysosomal acid lipase (LAL) used in biochemical and cellular research to probe lipid degradation pathways and to measure LAL activity in biological samples. It is supplied as a high-purity solid intended for in vitro assays and analytical applications.
- Potent LAL inhibition (IC50 152 nM) suitable for biochemical assays.
- High purity (≈99.9%) for reproducible results.
- Characterized molecular properties: formula C13H20N4O2S, molecular weight 296.39.
- Available in small solid quantities for research use.
- Stable when stored as powder: -20°C for 3 years, 4°C for 2 years.
- Short-term stability in solvent: -80°C for 6 months, -20°C for 1 month.
Medchemexpress LLC N-methyl-2-pyrrolidone | 872-50-4 | MFCD00003193 | 100.0% | 99.13 g/mol | C5H9NO | 50g
N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone) a five-membered cyclic amide is an orally active organic polar solvent with teratogenicity and toxicity N-Methylpyrrolidone is low in acute toxicity with a LD50 value of 3914 mg/kg in rats and of 4050 mg/kg in mice N-Methylpyrrolidone is extensively used in the manufacture of adhesives paints fuels and pharmaceuticals[1][2][3][4]
Medchemexpress LLC Sodium sulfate, anhydrous | 7757-82-6 | MFCD00003504 | 100.0% | 142.04 g/mol | Na2SO4 | 100g
Sodium sulfate anhydrous for cell culture is a drying agent in organic synthesis which can be used for cell culture[1]
Medchemexpress LLC 2,6-octadienal, 3,7-dimethyl-, (2Z)- | 106-26-3 | MFCD00213902 | 97.9% | 152.23 g/mol | C10H16O | 25mg
Neral is a monoterpene compound that has anti-inflammatory and anti-cancer properties Neral can inhibit TNF- and IL-6 and it also suppresses inflammatory mediators like pro-IL-1 iNOS COX-2 and NLRP-3[1][2]
Medchemexpress LLC Ammonium chloride-15N | 39466-62-1 | 98.0% | 54.48 | 15NH4Cl | 250mg
Ammonium chloride-15N is the 15N labeled Ammonium chloride (HY-Y1269) Ammonium chloride as a heteropolar compound with pH value regulation can cause intracellular alkalization and metabolic acidosis thus effecting enzymatic activity and influencing the process of biological system Ammonium chloride is an autophagy inhibitor Ammonium chloride is also a lysosome inhibitor[1][2][3]